O = Q = R (any moderate, severe or serious adverse event, insomnia, hypersomnia, sleepiness, urinary hesitancy, dry mouth, constipation, decreased sexual drive, sexual arousal, orgasm, incontinence, nocturia, sialorrhoea, orthostatic faintness, skin rash, AIMS, weight gain > 7%, rate of weight gain, change of blood glucose, HbA1c, QTc interval)O > Q > R (amount of weight gain) (p = 0.005;, (triglyceride change) (p = 0.03)O > R > Q (total cholesterol change) (p = 0.01)R > Q* > O* (change of prolactin level) (p < 0.001). The gene discussed is PRL; the disease is hypersomnia.