B6.Podocin/cre,Pdss2loxP/loxP but not B6.PEPCK/cre,Pdss2loxP/loxP mice had the same kidney disease phenotype as B6.Pdss2kd/kd missense mice, as judged by albuminuria and histological evidence of nephritis. The gene discussed is NPHS2; the disease is kidney disorder.