PDSS2 and Hypercholesterolemia: However, significantly elevated plasma cholesterol was also seen in B6.Alb/cre,Pdss2loxP/loxP (94 +/− 7.1 mg/dl) when compared with B6.Pdss2loxP/loxP controls (61 +/− 5.5 mg/dl), suggesting that a Pdss2 defect in the hepatocytes does contribute to hypercholesterolemia.