FGFR2 and Familial prostate cancer: rs13281615 in 8q24 was also more strongly associated with ER-positive and lower grade tumors, although differences were smaller than for rs2981582 in FGFR2. Other independent variants in the 8q24 region which does not contain known genes, have been associated with prostate cancer risk [11],[13],[14]; however, the mechanisms for the associations with these cancers are unknown.