INS and diabetes mellitus: However, since the Diabetes Control andComplication Trial demonstrated that, by well-controlling, the glucosemetabolism for the diabetic, especially type 1 diabetes patients, expectedemergence of complications can be delayed or protected, several techniques toreplace exogenous insulin to the lack of endogenous insulin in order tosuppress the rise of the amount of glucose in blood are developed, that is, theinsulin-dependent diabetes therapy.