Given the previous reported role of TNK2 in EGFR dynamics [17,19] and the potential impact of EGFR activation on migration and cytoskeleton remodelling [22,23], we hypothesised that the EGFR might be involved in the mechanism of action of TNK2 in breast cancer cells and hence be related to the observed morphological phenotype. This evidence concerns the gene TNK2 and breast carcinoma.