In summary, at the FDR level of 0.125, polymorphisms in 7 genes (LPA, CBS, APOC3, F7, APOB, SCNN1A, APOA4) are involved in susceptibility to a disturbed glucose metabolism (subjects who were IGM or who had T2DM), and susceptibility polymorphisms in 9 genes (SELE, ITGA2, APOB, GNB3, CETP, ADRB2, CBS, APOA4, APOC3) may predispose to T2DM. The gene discussed is CBS; the disease is type 2 diabetes mellitus.