The first group, which might influence susceptibility to disturbed glucose metabolism (i.e. IGM and T2DM combined), was formed by down-interactions between LPA(G121A) and CBS(844 68bp-/Ins), between APOC3(C1100T) and F7(-323 10-bp Del/Ins), and between APOB(Thr7Ile) and SCNN1A(Ala663Thr) and up-interactions between APOA4(Gln360His) and APOC3(C-641A). This evidence concerns the gene SCNN1A and type 2 diabetes mellitus.