For the gene-pairs that were significantly associated with T2DM, ADRB2(Gln27Glu)-CBS(Ile278/Ins), APOB(Thr7Ile)-CETP(Ile 405Val), APOA4(Thr347Ser)-APOC3(C1100T), APOB(Thr7Ile)-GNB(C825T), ITGA2(G873A)-SELE(Leu554Phe), we found that when the C-allele of APOB was present, the distribution of the C and T alleles of GNB3 differed between T2DM (n = 207 of which 15.9% were T) and non T2DM (n = 222 of which 26.6% were T, P = 0.007). The gene discussed is GNB3; the disease is type 2 diabetes mellitus.