The gene-pairs that were significantly associated with IGM or T2DM subjects, APOB(Thr7Ile)-SCNN1A(Ale663Thr), F7(-323 10-bp Del/Ins)-APOC3(C1100T), APOA4(Gln360His)-APOC3(C-641A), LPA(G121A), CBS(Ile278/Ins) were analysed in a similar way. The gene discussed is APOA4; the disease is type 2 diabetes mellitus.