BRCA1 and cancer: The findings of our study were: a) we determined that the BRCA1/2 negatives cancer patients that were carriers of the IVS24-9delT, IVS38-8T>C or 5557G>A showed an increase in brest cancer risk; b) we observed that all the carriers of IVS38-8C allele were also carriers of IVS24-9delT and 5557A alleles, a finding which suggests that IVS38-8T>C occurs in combination with the latter variants; and c) we established that the IVS24-9 T/(-T), IVS38-8 T/C, 5557G/A composite genotype confers a 3,19 fold increase in breast cancer.