Ten SNPs in the following six genes: NOD2 (2140 C/T, 2722 G/C), DLG5 (113 G/A), OCTN1 (1672 C/T), OCTN2 (-207 G/C), IL4 (-590 C/T) and TNFα (-308 G/A, -857 C/T, -863 C/A, -1031 T/C) were screened in a consecutive series of colorectal cancer patients using a two-staged approach. This evidence concerns the gene TNF and colorectal cancer.