Then, adult onset POAG loci, including GLC3B (2p36), GLC3A (2p21, CYP1B1), GLC1B (2cent-2q13), GLC1C (3q21–24), RIEG1 (4q25, PITX2), GLC1G (5q22, WDR36), IRID1 (6p25, FOXC1), GLC1F (7q35), GPDS1 (7q35-q36), GLC1D (8q23), Nail patella syndrome (NPS; 9q34, LMX1B), GLC1E (10p15-p14, OPTN), NNO1 (11p), AN2 (11p13, PAX6), VMD2 (11q12), MFRP (11q23), RIEG2 (13q14), GLC1L (15q11-q13), were genotyped; no linkage was found to any of these loci. The gene discussed is CYP1B1; the disease is open-angle glaucoma.