OPTN and glaucoma: No mutations were found by direct sequencing in the coding regions of any of the known glaucoma genes including MYOC, CYP1B1, WDR36, and OPTN. A whole genome scan using ABI Linkage Mapping Set v2.5 was performed using Family A. The scan revealed positive linkage to 2p15–16 with an LOD score of 5.01 at D2S337.