OPTN and open-angle glaucoma: Twenty-five loci have been associated with glaucoma [8,11], and four genes have been identified for monogenic glaucoma with Mendelian inheritance patterns including MYOC, CYP1B1, OPTN, and WDR36. MYOC is responsible for about 36% of juvenile-onset POAG cases and 2%–4% of adult-onset POAG cases [4,17,18].