No mutations were found by direct sequencing in the coding regions of any of the known glaucoma genes including MYOC, CYP1B1, WDR36, and OPTN. A whole genome scan using ABI Linkage Mapping Set v2.5 was performed using Family A. The scan revealed positive linkage to 2p15–16 with an LOD score of 5.01 at D2S337. The gene discussed is MYOC; the disease is glaucoma.