Family-based association performed in the ACS families using APL identified sixteen SNPs that were significant at p ≤ 0.05 (Figure 1, Additional files, Table 3), three of which also displayed linkage: rs10912660 in the ankyrin repeat domain 45 gene (ANKRD45), rs12092963 in the ral guanine nucleotide dissociation gene (RGL1), and rs1891586 in FAM5C (Figure 1, bold). This evidence concerns the gene BRINP3 and acute promyelocytic leukemia.