AGT and Nephropathy: In the Angiotensin II Antagonist Losartan Trial which recruited 1513 type 2 diabetic patients with nephropathy, high baseline albuminuria was associated with a 2.70-fold risk for HF compared with patients with low levels of albuminuria and that reduction of ACR at 6 months post treatment including the use of ARB predicted reduced risk of new onset of HF [32].