KIT and intrahepatic cholangiocarcinoma: A large number of in vitro studies have demonstrated the role of ICC as pacemakers with the evidence that can be summarized as follows: (1) ICC generate slow waves, (2) in the mutant animals where the ICC are absent, there are no slow waves and (3) in a specially prepared gastric tissue where ICC are obliterated by neutralizing antibody to Kit (activated Cdc42-associated kinase-2; ACK2), slow waves are absent [69].