Abnormal regulation of the late endosome–lysosome pathway could also contribute to neurodegeneration in other forms of CMT neuropathies like the dominant axonal CMT2B associated with mutations in RAB7, a GTPase implicated in the transport of proteins to lysosomes and the dominant demyelinating neuropathy CMT1C caused by mutations in the E3 ubiquitin ligase lipopolysaccharide-induced TNF factor (LITAF) that targets membrane proteins for lysosomal degradation through a monoubiquitination mechanism (97,98). Here, LITAF is linked to Charcot-Marie-Tooth disease type 1C.