Among them are many genes with previous links to esophageal cancer or to cancers in general: histone biomarkers, gravin, HLA-DRA, keratin 8 (KRT8), glutathione peroxidase 2 (GPX2), the mitotic checkpoint protein kinase BUB1B, the progestin-induced protein DD5 and transglutaminase 3. The gene discussed is AKAP12; the disease is esophageal cancer.