A similar role for DCs has been described for HIV-1, where DCs capture HIV-1 via the C-type lectin dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) and mediate transmission of HIV-1 to T-lymphocytes by de novo production of virus or transferring the virus particles directly to the T-lymphocytes (trans-infection) [9],[10]. Here, CD209 is linked to infection.