Knock-down of LASP-1 by RNA-interference in metastatic breast and ovarian cancer cell lines did not lead to induction of apoptosis or necrosis but to strong inhibition of migration and proliferation with cell cycle arrest in G2-phase, while artificial over-expression of LASP-1 in non-neoplastic PTK2 cells resulted in a dramatic acceleration of migration [38,39]. The gene discussed is LASP1; the disease is ovarian carcinoma.