At focal adhesions the C-terminal SH3 domain of LASP-1 is involved in protein-protein interactions through binding to proline-rich sequences, specifically with palladin, lipoma preferred partner (LPP), Prointerleukin-16 (Pro-IL-16), vasodilator stimulated phosphoprotein (VASP) and zyxin [10,26,27,13]. This evidence concerns the gene IL16 and lipoma.