Similarly, a CPVT-like arrrhythmogenesis has been observed under conditions of adrenaline and/or caffeine perfusion in a recent murine model with RyR2 modifications targeted instead at the C-terminal luminal sites implicated in store-overload-induced Ca2+ release (SOICR) (Jiang et al. 2004, 2005, Cerrone et al. 2005). Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.