There has been extensive discussion about the association between mutations in the RyR2, including that of P2328S, and the CPVT phenotypes, particularly concerning possible roles of FKBP12.6-RyR2 binding (Brillantes et al., 1994; Masumiya et al. 2003, Zissimopoulos & Lai 2005, Thomas et al. 2006). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.