We also calculated adjusted hazard ratios for the 11823860_ST2 gene set in the three datasets (Sotiriou_2, van de Vijver, and Sorlie_1) for available clinical parameters such as grade, lymph node status, tumor size, age, and estrogen receptor (ER) status (Additional data file 2, Supplementary Table 5, 6 and 7). Here, ESR1 is linked to neoplasm.