APCmin/+, SIRT1STOP control mice that did not overexpress SIRT1 (referred to as SIRT1STOP) showed the typical signs of tumor morbidity at 16 weeks of age, as evidenced by overt anemia and cachexia, whereas APCmin/+ mice overexpressing SIRT1 (SIRT1ΔSTOP) displayed no overt signs of tumor associated morbidity (Fig. S1A, B). Here, SIRT1 is linked to neoplasm.