We chose to test the effect of SIRT1 in the APCmin/+ model of colon cancer for a variety of reasons: it physiologically recapitulates the early events of colon cancer in humans, the mechanism of tumorigenesis is well characterized, and CR has previously been shown to reduce the rate of tumorigenesis in this model [16]. This evidence concerns the gene SIRT1 and malignant colon neoplasm.