In Ghanaian school children living in an area highly endemic for parasitic infections, there was a significantly higher expression of TLR2 in subjects with positive skin reactivity to house dust mite (Figure 2A); high expression of TLR2 doubled the risk of atopy (OR 2.6, Table 2), whereas there was no such association for TLR4 and skin reactivity (OR 0.9; Table 2 and Figure 2B). The gene discussed is TLR4; the disease is parasitic infectious disease.