CIMP+ tumours occur more frequently in the proximal colon of older patients and are associated with the microsatellite instability (MSI+) phenotype, tumour-infiltrating lymphocytes (TILs) and mutations in the BRAF oncogene (Hawkins et al, 2002; van Rijnsoever et al, 2002; Samowitz et al, 2005). This evidence concerns the gene BRAF and neoplasm.