CIDEC and obesity due to melanocortin 4 receptor deficiency: Specifically, we computed edge orienting scores for the edge Fsp27 → MEblue where Fsp27 (also known as Cidec) corresponds to a pro-apoptotic gene that is related to metabolic syndrome: Fsp27-null mice have been found to be resistant to obesity and diabetes; Fsp27 expression is halved in obese humans after weight loss; and Fsp27 regulates lipolysis in white human adipocytes [53].