Neutrophil-derived, MMP-9-mediated tissue degradation and the instructional role of MMP-9 in directing the inflammatory response are key, and perhaps critical, events in the etiology of chronic obstructive pulmonary disease (COPD) [38]; systemic and cerebral vascular diseases [39], asthma [2,5], and periodontitis[6]. This evidence concerns the gene MMP9 and periodontitis.