Furthermore, gain of 17q12, harbouring ERBB2, was observed in 9 tumors and 6 of these showed concomitant gain of 7p11.2 (EGFR), which suggests that co-overexpression of ERBB2 and EGFR may apply also to ESCC [33]. Here, ERBB2 is linked to esophageal squamous cell carcinoma.