IL10 and Pyle disease: In agreement with these observations, Kobayashi et al [7] have reported that IL-10 is produced very early during PyL (but not during PyNL) infection and Perry et al [23] have reported a switch from IL-12 (at day 3 pi) to IL-10 (at day 17 pi) production by splenic dendritic cells during the course of a non-lethal Py infection.