Whenactivated VEGFR2 initiates signaling that leads to endothelial cellproliferation and also to expression of cytoprotective antiapoptotic molecules [36].VEGFR2 is detectable only at relatively low levels in the adult vasculature; itis markedly up regulated by blood vessels during chronic inflammation, hypoxia,tumor growth, and wound repair. This evidence concerns the gene KDR and neoplasm.