These include immune modulation, lipid regulation, and oxidant/antioxidant pathways important to the onset and progression of “dry” AMD, and vascular endothelialgrowth factor (VEGF) mediated pathways that stimulate choroidalneovascularization (CNV), characteristic of “wet” AMD.PPAR-α is found in retina and also on vascular cellsimportant to formation of CNV. The gene discussed is PPARA; the disease is age-related macular degeneration.