With their pleiotropic effects onlipid metabolism, glucose homeostasis, myocardial energetics, and responses toischemia, as well as the considerable evidence linking genetic polymorphismsidentified within the PPAR complex to common cardiovascular diseases, the PPARfamily of transcription factors is central to the regulation of a number of keycellular pathways that impact on normal and pathologic cardiovascularphysiology and thus represent very promising targets for further advances inpharmacologic intervention. Here, PPARA is linked to cardiovascular disorder.