PTGS2 and amyotrophic lateral sclerosis: First, PPARγ activation may reduce theoverall level of free radicals present in the injured tissue since PPARγ activation leads to decreasednitric oxide, cyclooxygenase-2 (COX-2),iNOS, and nitrotyrosine levels in animal models of amyotrophic lateralsclerosis (ALS), multiplesclerosis (MS), ischemia, and neuroinflammation [31–37].