There was no significant difference in the average Prox1 mRNA expression level in normal liver, in non-cirrhotic or cirrhotic peritumoral liver, in liver cirrhosis, in HCC and in CCC compared to normal human liver, or compared with each other (p = 0.7932, with One-way ANOVA, Figure 5A, Table 2). Here, PROX1 is linked to cirrhosis of liver.