In contrast, no other cytokine genes from the panel were up-regulated, but a cluster of genes related to the NF-κB pathway was down-regulated, including NFΚB1, NFΚB2, TNFR1, IL1B, IL8 and TNFA. In addition, the NF-κB pathway linked expression patterns of NFΚB1, TNFR1 and TNFA correlated with adverse clinical events, such as the development of pleural effusion and hemorrhagic manifestations. Here, TNFRSF1A is linked to Pleural effusion.