In the current study, the in vivo role of ten TLRs during dengue infection was explored and differential gene expression of TLRs was found: increased expression of TLR7 and TLR4R3 together with a decreased expression of TLR1, TLR2, TLR4R4 and TLR4 co-factor CD14. These results show that the transcription profile of the total white blood cells is perturbed in children with severe dengue disease; the lack of clustered data hampers further interpretation of these results. Here, TLR4 is linked to dengue disease.