In conclusion, the information-theoretic analysis of the statistical dependencies of the MDM2 SNP309 locus and gender upon the age of tumor onset in p53 mutation carriers suggests that the G-allele of SNP309 functions primarily in female p53 mutation carriers to accelerate tumor formation, thereby providing a potential genetic basis for observed sexual dimorphism in cancer risk [21], [22]. This evidence concerns the gene MDM2 and cancer.