Specifically, the G-allele of MDM2 SNP309 was shown to accelerate tumorigenesis and increase cancer risk in women and not in men for colorectal cancer, diffuse large B-cell lymphoma, lung cancer and for highly estrogen receptor positive (>50% of tumor cells), but not for estrogen receptor negative, invasive ductal carcinoma of the breast[16], [18], [19]. This evidence concerns the gene ESR1 and lung carcinoma.