In line with previous reports identifying oligodendroglial lineage markers such as Olig2 or NG2/PDGFRα as universal markers in diffuse gliomas [1]–[3], our study demonstrates the shared pattern of concomitant expression of multiple surface markers between glioma cells and oligodendrocyte progenitor cells, which suggests that most of the morphologically diagnosed astrocytoma and GBM are endowed with oligodendrocyte lineage differentiation potential. This evidence concerns the gene OLIG2 and glioma.