Thus, low-grade glioma cells may resemble the expansion of A2B5+ glial progenitor-like cells; high-grade gliomas, in addition to the expansion of A2B5+ glial progenitor-like cells, may also contain CD133+ putative glioma stem cells that concomitantly express multiple surface markers of glial progenitor cells. Here, PROM1 is linked to glioma.