The T allele of the PHB 3'UTR polymorphism has recently been shown to be associated with an increased risk of breast cancer (ORadj, 2.12; 95% CI, 1.23–3.70) [10] in Polish women carrying one of the three common BRCA1 founder mutations that account for approximately 90% of all detected BRCA1 mutations detected in this country [11,12]. This evidence concerns the gene BRCA1 and breast cancer.