EGFR and glioblastoma: Using a rule-based algorithm to define minimal common regions (MCRs) of CNAs based on amplitude, width, and recurrence of CNAs (Aguirre et al., 2004; Carrasco et al., 2006; Tonon et al., 2005), we readily identified the signature genomic events known previously for GBM (e.g., EGFR amplification or CDKN2A deletion) as well as many previously uncharacterized alterations (Table S2).