In addition to a large body of literature implicating the Myc network in GBM (Bredel et al., 2005), as well as presence of MYC amplification in GBM (Table 1, no. 6), FBXW7 expression itself has recently been correlated with GBM patient survival (Hagedorn et al., 2007) although a direct pathogenetic role in GBM has not been established. The gene discussed is FBXW7; the disease is glioblastoma.