Conversely, we examined the consequences of p16INK4A and p18INK4C reconstitution in U87MG and LN-229, two established GBM cells with concomitant deletions of the p16INK4A and p18INK4C loci as documented by copy number profiling and/or qPCR (data not shown). This evidence concerns the gene CDKN2A and glioblastoma.