A final gene worthy of note is mediator of RNA polymerase II transcription subunit 28 homolog (S. cerevisiae, MED28): Previous work has shown MED28 to be significantly up-regulated in tumours, its over expression is able to stimulate cellular proliferation and its expression is up-regulated by endothelial cells when exposed to tumour media [39,40]. Here, MED28 is linked to neoplasm.