The integrins αvβ3 and αvβ5 have been demonstrated to be necessary for tumor‐induced angiogenesis in a variety of tumors, particularly malignant gliomas via basic fibroblast growth factor (bFGF) and tumor necrosis factor α (TNF‐α) 9, 10, 15. The gene discussed is TNF; the disease is malignant glioma.