TGFB1 and inflammatory response: In these studies,bone-marrow transplantation was performed in mice to induce TGF-β1-mediatedskin fibrosis and inflammation.[5] The investigators asked if systemic therapy withrecombinant LAP abrogated the development of skin fibrosis in this animal model.While the data showed an expected reduction in TGF-β1 signaling andfibrosis, there was persistent monocytic inflammation in the skin.