CED is a disorder associated withabnormal bone growth and multiple other systemic abnormalities.[30] Two groups recentlyreported that this disorder was associated with several missense mutations in theLAP region of the TGF-β1 gene that affects its ability to bind toTGF-β1 and confer latency.[31] It is possible that some of the phenotypicabnormalities in CED patients may be related to changes in LAP and resultantdownstream signaling events. The gene discussed is TGFB1; the disease is cranioectodermal dysplasia.