Although a mutant strain of yeast in which the delta subunit of F1F0-ATP synthase had been inactivated by insertional mutagenesis showed little or no ATPase activity(Giraud and Velours, 1994), and dysfunction of ATP synthase can cause a variety of degenerative diseases(Wallace, 1994), there have been no previous reports detailing a relationship between ATP synthase and tumorigenesis. This evidence concerns the gene DNAH8 and neurodegenerative disease.