After C-peptide infusion,glucose utilisation increased in patients with diabetes mellitus (51.5 ± 25.6 versus 74.51 ± 22.93 g) and healthy controls (74.91 ± 22.01versus 99.38 ± 24.24 g) statistically significant (P < .001)during high-dose insulin infusion and from 16.31 ± 13.34 to 18.8 ± 16.2 g in the diabetic patients and from 20.74 ± 9.96 to 35.8 ± 13.5 gin the healthy controls, the results are given in Figure 2 [11]. This evidence concerns the gene INS and diabetes mellitus.