Elevated levels of cholesterol have emerged as a risk factor for both stroke [33] and Alzheimer's disease [34] and others and we have shown that cholesterol-enriched diets induce pathological features of Alzheimer's disease such as learning deficit, increased Aβ plaque formation, hyperphosphorylation of tau, and neuronal cell death [10,25,35-37]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.