MTHFR and open-angle glaucoma: To assess the association of C677T polymorphism of MTHFR in the Pakistani population, we took 90 POAG patients with the mean age of 57.9±14.3 years (64.4% males and 35.5% females), 60 PCAG patients with the mean age 57±10.05 years (51.67% males and 48.3% females), and 70 control subjects with the mean age of 50.9±8.1 years (66% males and 34% females).