The aims of this study were (1) to compare two human primary UM cell lines (92–1, Mel202) and two human primary CM cell lines (FM55P, IGR-39) in terms of their adhesion and migration (wound healing) to FN; (2) to determine the repertoire of integrins acting as FN receptors on these melanoma cells; (3) to test whether the oligosaccharides of surface N-glycoproteins influence melanoma cell behavior; (4) to measure the surface expression of β1–6 branched N-oligosaccharides on melanoma cells; and (5) to identify the FN receptors bearing β1–6 branched N-oligosaccharides. The gene discussed is FN1; the disease is melanoma.