Further investigations showed PTTG-1 to be highly expressed in different tumor cell lines (promyelocytic leukemia cell line HL-60, HeLa cell S3, chronic myelogenous leukemia cell line K-562, lymphoblastic leukemia cell line MOLT-4, Burkitt's lymphoma cell line Raji, colorectal adenocarcinoma cell line SW480, lung carcinoma cell A549, melanoma cell G361) [12]. Here, PTTG1 is linked to lung carcinoma.