In our study, angiogenesis, as evaluated by the measurement of MVD, was observed before any significant fibroblastic stromagenesis, since a high microvessel count was found in all in situ ductal carcinomas and to a lesser extent around glands harboring ADH, FA, LCIS and ALH, while stromagenesis was mostly observed around ducts harboring DCIS-I and DCIS-H. The gene discussed is AVP; the disease is breast ductal adenocarcinoma.