Interestingly, XX Foxl2-/- mice show an early disruption of folliculogenesis that recapitulates a phenotype of Premature Ovarian Failure (POF) also encountered in XX BPES type I patients (Blepharophimosis Ptosis Epicanthus inversus Syndrome, MIM#110100) carrying a heterozygous mutation of the FOXL2 gene [23-26]. This evidence concerns the gene FOXL2 and premature menopause.