Interestingly, miR-34, which was recently reported to mimic TP53 activity[8], [9], [10], [11], [12], was downregulated in the sensitive cell lines in the 5-fluorouracil and paclitaxel microRNA signatures, indicating a possible connection between chemosensitivity to those drugs and the well-known TP53 tumor suppressor network. This evidence concerns the gene TP53 and neoplasm.