In addition, in the well-differentiated mouse hepatoma cell line mhAT3FS315, carrying a dominant negative form of the HNF3 transcription factor, inhibiting expression of genes controlling the hepatocyte phenotype [18], the expression of V3C18 mRNA was 22% of that in the parental cell line mhAT3F (Figure 1C). The gene discussed is FOXM1; the disease is hepatocellular carcinoma.