WNT3A and neoplasm: In addition, the N-terminus of the V3C18 is partially processed to a FZC18 precursor (V3Nter) which pulls down Wnt3a in vitro, suppresses Wnt/β−catenin signaling and downstream gene expression, reduces tumor cell growth and increases cell death in CRC and HCC cell lines carrying activating β−catenin mutations.