TLR4 and HELLP syndrome: In women with early-onset preeclampsia complicated by HELLP syndrome (N = 177), positivity for one or more allelic variants of TLR4 was observed in 1 out of 4 women, with an crude odds ratio of 4.7 (95% CI 2.0 to 10.9) and adjusted odds ratio of 4.1 (95% CI 1.7 to 9.8), when compared to controls with only uneventful pregnancies (Figure 1b).