Overall, highest odds ratios for early-onset preeclampsia were observed for women carrying any of the five allelic variants of TLR4 or NOD2, within the highest tertiles for IL-6 and fibrinogen, with ORs of 6.9 (95% CI 2.1 to 23.2; P for trend 0.03 after adjustment for confounding variables) for IL-6 and 3.8 (95% CI 1.2 to 11.8; adjusted P for trend 0.04) for fibrinogen, respectively. This evidence concerns the gene TLR4 and preeclampsia.