In addition, TLR4 polymorphisms were significantly more common in women who developed HELLP syndrome, when compared to women with preeclampsia only (excluding those with HELLP) with an OR of 2.3 (95% CI 1.3 to 4.3) after adjustment for maternal age and chronic hypertension (Figure 1c). The gene discussed is TLR4; the disease is preeclampsia.