Compared to women with plasma levels within the lowest tertiles of the control distribution and negative for any of the TLR4 and NOD2 polymorphisms, the highest tertiles of fibrinogen and IL-6 and the presence of attenuating allelic variants of TLR4 or NOD2 showed both independent and combined associations with a history of early-onset preeclampsia. The gene discussed is IL6; the disease is preeclampsia.