Cmet has previously been detected in 52–87% of STS (Fukuda et al, 1998; Kuhnen et al, 2003) and, an important proto-oncogene itself, also enables sarcoma cells to become hyper-responsive to HGF, a ubiquitously expressed effector of cell proliferation, motility and invasiveness (Cortner et al, 1995). Here, HGF is linked to sarcoma.