However, all the aforementioned comparisons are prone to residual confounding; therefore we performed multi-adjusted logistic regression analysis which revealed that increased age (p < 0.001), waist circumference (p = 0.03), fasting glucose (p = 0.08) and apolipoprotein B (p = 0.001) levels, were the most significant baseline predictors of developing hypercholesterolemia within a 5-year period (Table 3). Here, APOB is linked to familial hypercholesterolemia.