Moreover, presence of all the aforementioned baseline characteristics (i.e., age > 45 y, waist circumference > 95/82 cm (men/women), fasting glucose >100 mg/dl and apolipoprotein B > 100 mg/dl) 20.2-fold the risk of developing hypercholesterolemia within the 5-year period (95% CI 18.7 to 21.7). The gene discussed is APOB; the disease is familial hypercholesterolemia.