APOB and familial hypercholesterolemia: Moreover, from the baseline blood lipids measurements ROC analysis showed that apolipoprotein B (AUC = 0.75), followed by triglycerides (AUC = 0.727), total cholesterol (AUC = 0.70), LDL-cholesterol (AUC = 0.62), HDL-cholesterol (AUC = 0.55) and apolipoprotein AI (AUC = 0.54) were all significantly associated with the development of hypercholesterolemia.